Objective. To study the awareness of the population of the Amur region about arterial hypertension (AH) and to assess the prevalence of the disease, the level of control and treatment adherence within the framework of the annual screening campaign “Measure Your Blood Pressure.”

Materials and methods. During the period from 2023 to 2025, a screening of 324 residents of the Amur region was conducted. Blood pressure (BP) measurements were performed using automatic and mechanical tonometers. Participants completed a questionnaire that included questions about the presence of hypertension, cardiovascular diseases, diabetes mellitus, smoking, history of COVID-19, and use of antihypertensive drugs. Hypertension was diagnosed at systolic BP ≥140 mmHg, diastolic BP ≥90 mmHg, or receiving therapy. Statistical analysis was performed using Statistica 10.0 software.

Results. Elevated BP was detected in an average of 49.5% of participants, with a predominance among women and middle-aged/elderly individuals. In 2025, compared to 2024, a 1.5-fold increase in hypertension among men was revealed. A significant prevalence of risk factors was noted: smoking (60.4%), overweight and obesity (38.6%), history of COVID-19 (90.8%). The proportion of individuals with newly diagnosed hypertension increased from 15.3% in 2023 to 28.5% in 2025, mainly among young men. Only 45.3% of patients with hypertension received antihypertensive therapy, while the target BP level was achieved in only 41.1%, indicating low adherence and insufficient treatment effectiveness.

Conclusion. The screening confirmed a high prevalence of hypertension among the population of the Amur region with a low level of awareness, especially among men. Insufficient treatment adherence and low effectiveness of antihypertensive therapy were revealed. It is necessary to strengthen educational work on hypertension risk factors, the importance of regular BP monitoring, and preventive measures.

Objective. To evaluate the results of comprehensive treatment of liver abscesses using minimally invasive technologies.

Materials and methods. The results of comprehensive treatment of 31 patients with liver abscesses who underwent interventions under navigation in the surgical department of Blagoveshchensk City Clinical Hospital were analyzed. The age of patients ranged from 26 to 73 years, working-age individuals accounted for 23 (74.1%) patients, males predominated – 87.1% (27 persons).

Results. In patients with liver abscesses, signs of severe intoxication were characteristic. Fever with chills was detected in 27 (87.1%), dull constant pain in the right hypochondrium or epigastric region – in 25 (80.6%), decreased appetite, weakness, fatigue – in 23 (71.4%), yellowing of the skin – in 27 (87.1%). The severity of the condition in patients with liver abscesses, as a rule, is due to the development of abdominal sepsis, therefore, treatment of such patients was carried out jointly with intensive care specialists in the intensive care unit.

Conclusion. Comprehensive treatment of liver abscesses using minimally invasive technologies allows achieving better results at lower costs, reducing the number of postoperative complications, as well as reducing the length of hospital stay.

Background. Despite a wide variety of studies devoted to the search for means of prevention and correction of postural disorders, the number of children with musculoskeletal pathology is steadily increasing.

Objective. To study the effect of Kyokushinkai karate training on flexibility and the condition of the muscle corset in children aged 8–10 years.

Materials and methods. The study involved 20 children aged 8–10 years, divided into 2 groups: 10 children who had been practicing Kyokushinkai for no more than 2 months, and another 10 – a control group of children not engaged in karate. Using special tests, muscle endurance and spinal flexibility indicators were examined before and after the experiment. Only children with moderate postural disorders were included in the study. For assessing the state of the musculoskeletal system, the main method was somatoscopy. The training sessions were conducted by a coach-instructor together with the author of the study in the karate section 3 times a week. In addition, all karate children, under the guidance of their parents, followed recommendations for performing a set of exercises on rest days. These sets were selected individually based on the type of postural disorder and took about 20 minutes per day. Children in the control group engaged in extracurricular activities in terms of hours, as well as at home under the guidance of their parents.

Results. Against the background of training, positive dynamics in the formation of posture in children was observed in both subgroups. In karate children, the depth of cervical and lumbar curves began to correspond to the age norm. The changes were significant (p0.05). Insignificant positive dynamics were also revealed in the symmetry of the shoulder girdle.

Conclusion. Kyokushinkai karate exercises, as well as individual selection of additional recommendations for independent practice at home, have a positive effect on posture formation.

Objective. To study the clinical features of SARS-CоV-2-associated pneumonia in patients with multiple myeloma (MM).

Materials and methods. A retrospective study was conducted analyzing outpatient records and case histories of patients with MM complicated by SARS-CоV-2-associated pneumonia who were treated at the Irkutsk Regional Clinical Hospital (Order of the Badge of Honour) and infectious disease hospitals in 2020–2022.

Results. In 2020–2022, SARS-CоV-2-associated pneumonia ranked first in the structure of infectious complications in MM (24% of the total number of infectious episodes). Higher incidence was registered in patients with decreased normal immunoglobulin G levels < 5 g/L. Lower incidence of SARS-CoV-2 infection was noted upon achievement of MM response (remission) compared with newly diagnosed and relapsed patients (p=0.035 and p < 0.001). Predictors of fatal outcome in MM patients with COVID-19- associated pneumonia were: grade 4 lung involvement, decreased normal IgG < 5 g/L, neutropenia < 0.5×10⁹ /L, chronic kidney disease stage 3–5, ECOG performance status 3–4, and elderly age.

Conclusion. New data have been obtained that can be used for the diagnosis and treatment of SARS-CоV-2-associated pneumonia in MM patients.

The article presents a clinical observation of diffuse non-Hodgkin lymphoma with predominant involvement of the spleen and abdominal lymph nodes in a 59-year-old female patient, which during life manifested "under the guise" of fever of unknown origin, severe intoxication syndrome, and profound anemia. Instrumental studies revealed significant splenomegaly and a large focal lesion of the spleen in the absence of convincing evidence confirming gastrointestinal mucosal involvement. According to the results of trephine biopsy, the bone marrow material contained no reliable signs of specific lymphoid involvement. Final verification of the lymphoma was obtained posthumously based on an autopsy study with morphological confirmation of diffuse infiltration of the spleen by atypical large lymphoid cells with high mitotic activity and destruction of the organ architecture. This case demonstrates the limitations of antemortem diagnosis of lymphoproliferative diseases with predominantly visceral involvement and highlights the role of pathological autopsy as a tool for quality control of diagnosis.

The article presents a clinical observation of a hypertensive crisis in a 23-year-old patient with previously undiagnosed renovascular arterial hypertension. Insufficient diagnostic control led to a crisis course of the disease and early target organ damage.

This case highlights the importance of thorough examination of every patient with elevated blood pressure aimed at excluding secondary hypertension, and demonstrates the need for in-depth followup monitoring, especially in young adults.

The article presents a clinical observation of comorbid pathology: hematogenic thrombophilia, combined form (F5 Leiden mutation – heterozygous, MTHFR – homozygous, hyperhomocysteinemia) and ulcerative colitis. Both of these diseases have increased thrombogenicity (hereditary and acquired thrombophilia); in this case, thrombosis of the lower extremity veins, post-thrombotic syndrome, and recurrent pulmonary embolism were detected. The presence of ulcerative colitis and intestinal bleeding complicated the therapy of acute thrombosis and secondary prevention of thrombus formation. After achieving remission of ulcerative colitis, it became possible to carry out full-scale secondary prevention of thrombus formation. Subsequently, no recurrences of thrombosis were registered in this patient.

Conclusion. The possibilities of diagnosis and therapy of comorbid pathology accompanied by thrombotic complications and intestinal bleeding are demonstrated, which may be useful for practicing physicians.

Background. The search for modifications of biodegradable tissue-engineered products (BTEP) for the treatment of deep frostbite remains an urgent problem in the medicine of critical temperature exposures.

Objective. To study the morphology and closure rate of deep skin frostbite wound defect in laboratory animals using standard therapy and its combination with BTEP implantation.

Materials and methods. The study was performed on 70 male Wistar rats. Rats of the control and experimental groups were modeled with deep contact frostbite of III degree of the back skin, after which the control group received standard frostbite therapy, the experimental group additionally received BTEP implantation. Animals were sacrificed on days 3, 7 and 14 of the experiment. The wound defect closure rate and morphometric parameters in skin preparations were determined.

Results.  On day 3, plethoric vessels with persistent spasm were determined in the control and experimental groups. On day 7, in the experimental group, active ingrowth of dermal fibers into the BTEP implantation zone was observed, the wound epithelialization rate was higher (p=0.037). On day 14, a branched microvasculature network without signs of congestive insufficiency was formed in the experimental group.

Conclusion. The use of BTEP accelerates dermal regeneration, ensuring the formation of full-fledged connective tissue.

Background. Despite the methods of cardiovascular diseases diagnosis and treatment constantly evolving, the prevalence of such diseases remains high with a tendency to increase. This refers both to complications and risk factors of cardiac pathology, including arterial hypertension as an important factor. Under these circumstances, telehealth technologies that allow monitoring of patients' condition and treatment adherence, timely correction of therapy and rehabilitation processes, optimization of medical staff workflow, and saving of healthcare resources become particularly relevant.

Objective. To confirm, based on an analysis of research results presented in scientific databases, the relevance and effectiveness of telehealth technologies for remote monitoring of patients with arterial hypertension.

Material and methods. We searched eLibrary, CyberLeninka, PubMed, MEDLINE, Cochrane Library, and Google Scholar for Russian and international studies using the following key words: “telemedicine,” “telecardiology”, “remote monitoring”, “arterial hypertension”, “cardiovascular disease risk factors”, “cardiac rehabilitation”.

Results. Telemedicine tools, particularly remote monitoring, can play a significant role in the follow-up, treatment adjustment, and rehabilitation of patients with arterial hypertension, reducing hospitalization rates and mortality. These technologies optimize physician workload, lower healthcare costs, and promote patient adherence to self-monitoring of blood pressure and prescribed therapy.

Conclusion. That telemedicine technologies applied to patients with arterial hypertension will continue to advance and strengthen their position among traditional methods of prevention, diagnosis, treatment, and rehabilitation.

Acute intestinal obstruction is a common problem in abdominal surgery, occupying a special place among all other acute diseases of the abdominal organs requiring emergency surgical care. A large number of works devoted to the diagnosis, treatment and prevention of intestinal obstruction can be found in the literature; despite this, hospital mortality reaches up to 6% among patients seeking treatment for this pathology, the majority of whom are patients with strangulation obstruction.

Objective. To systematize current data concerning the problems of etiopathogenesis, clinical presentation, diagnosis and treatment of strangulation ileus.

The main material for writing the review consisted of publications by Russian and foreign authors available in specialized databases (PubMed, Scopus, eLibrary) over the past 10 years. The most complex form of acute intestinal obstruction is still considered to be strangulation ileus, which occurs due to compression of the mesentery supplying the intestine. The "gold standard" of instrumental diagnosis currently remains double-contrast tomography, the results of which determine the choice of surgical operation, which is the only treatment method for strangulation obstruction.

Difficulties in conducting differential diagnosis at the stage of history taking and manual examination methods require a more detailed study and search for pathognomonic signs that would allow distinguishing obstructive ileus from strangulation ileus at the prehospital and early hospital stages.