Combination of Hereditary Hematogenic Thrombophilia and Ulcerative Colitis: A Case Report
Yu. M. Demenko, 
V. V. Voytsekhovsky,
L. A. Trusova,
O. A. Abuldinova,
E. I. Smorodina,
Yu. V. Suslova
V. V. Voytsekhovsky,
L. A. Trusova,
O. A. Abuldinova,
E. I. Smorodina,
Yu. V. Suslova https://doi.org/10.22448/AMJ.2026.1.43-50
EDN: TPLYDA
Abstract
The article presents a clinical observation of comorbid pathology: hematogenic thrombophilia, combined form (F5 Leiden mutation – heterozygous, MTHFR – homozygous, hyperhomocysteinemia) and ulcerative colitis. Both of these diseases have increased thrombogenicity (hereditary and acquired thrombophilia); in this case, thrombosis of the lower extremity veins, post-thrombotic syndrome, and recurrent pulmonary embolism were detected. The presence of ulcerative colitis and intestinal bleeding complicated the therapy of acute thrombosis and secondary prevention of thrombus formation. After achieving remission of ulcerative colitis, it became possible to carry out full-scale secondary prevention of thrombus formation. Subsequently, no recurrences of thrombosis were registered in this patient.
Conclusion. The possibilities of diagnosis and therapy of comorbid pathology accompanied by thrombotic complications and intestinal bleeding are demonstrated, which may be useful for practicing physicians.
Keywords
hematogenic thrombophilia,
ulcerative colitis,
comorbid pathology,
thrombotic complications,
intestinal bleeding
Supporting agencies: The study was not sponsored.
About the Authors
Yu. M. Demenko
Amur State Medical Academy
Russian Federation
Russian Federation
Yulia M. Demenko
Blagoveshchensk
V. V. Voytsekhovsky
Amur State Medical Academy
Russian Federation
Russian Federation
Valery V. Voytsekhovsky
Blagoveshchensk
L. A. Trusova
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Liliya A. Trusova
Blagoveshchensk
O. A. Abuldinova
Amur State Medical Academy
Russian Federation
Russian Federation
Olga A. Abuldinova
Blagoveshchensk
E. I. Smorodina
Amur State Medical Academy
Russian Federation
Russian Federation
Elena I. Smorodina
Blagoveshchensk
Yu. V. Suslova
Amur State Medical Academy
Russian Federation
Russian Federation
Yulia V. Suslova
Blagoveshchensk
References
1. Barkagan Z.S. Prethrombotic conditions and thrombophilia. Handbook of hematology. Edited by A.I. Vorobyov. Moscow: New-diamed, 2005. Vol. 3. pp. 133–147.
2. Momot A.P. Modern methods for recognizing the state of thrombotic readiness. Barnaul: Publishing House of Altai State University, 2011. 138 p.
3. World Health Organization: Inherited Thrombophilia: Report of a Joint WHO. International Society of Thrombosis and Haemostasis (ISTH) Meeting. Geneva: World Health Organization, 1995.
4. Bates S.M., Greer I., Pabinger I., et al. Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008; 133 (6 Suppl). 844–886. DOI: https://doi.org/10.1378/chest.08-0761
5. Clinical Practice Guidelines “Ulcerative Colitis 2024–2026”. 63 p.
6. Travis S., Dinesen L. Remission intrials of ulcerative colitis: what does it mean? Practical Gastroenterology. 2010; 30: 17–20.
7. Dignass A., Eliakim R., Magro F., et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis. Journal of Crohn's and Colitis. 2012; 6 (10): 965–990. DOI: https://doi.org/10.1016/j.crohns.2012.09.003
8. Borota A.V., Borota A.A., Onishchenko E.V. Thrombotic complications in inflammatory bowel diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019; 29 (2): 23–26. DOI: https://doi.org/10.22416/1382-4376-2019-29-2-23-26
9. Fadeeva N.A., Donchenko I.A., Knyazev O.V., et al. A clinical case of hereditary thrombophilia in a patient with ulcerative colitis. Almanac of Clinical Medicine. 2017; 45 (5): 423–428. DOI: https://doi.org/10.18786/2072-0505-2017-45-5-423-428
10. Fedulova E.N., Khavkin A.I., Medyantseva G.V., Tsarev V.A. Ulcerative colitis, hereditary thrombophilia, and coronavirus infection as links in the same chain: a clinical case of comorbidity in a 12-year-old girl. Issues in Practical Pediatrics. 2023; 18 (3): 133–136. DOI: https://doi.org/10.20953/1817-7646-2023-3-133-136.
11. Panchenko E.P., Balakhonova T.V., Danilov N.M., et al. Diagnosis and treatment of pulmonary embolism: clinical guidelines of the Eurasian Association of Cardiologists for practicing physicians. Eurasian Journal of Cardiology. 2021; 1: 44–77. DOI: https://doi.org/10.38109/2225-1685-2021-1-44-77
12. Christiansen S., Cannegieter S.C., Koster T., et al. Thrombophilia, clinical factors, and recurrent venous thrombotic events. JAMA. 2005; 293 (19): 2352– 2361. DOI: https://doi.org/10.1001/jama.293.19.2352
13. Snezhitsky V.A., Snezhitsky V.A., Pirochkina V.M. Clinical aspects of hyperhomocysteinemia. Grodno: Grodno State Medical University, 2011; 292 p.
Review
For citations:
Demenko Yu.M., Voytsekhovsky V.V., Trusova L.A., Abuldinova O.A., Smorodina E.I., Suslova Yu.V. Combination of Hereditary Hematogenic Thrombophilia and Ulcerative Colitis: A Case Report. Amur Medical Journal. 2026;14(1):43-50. (In Russ.) https://doi.org/10.22448/AMJ.2026.1.43-50. EDN: TPLYDA
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