Combination of Hereditary Hematogenic Thrombophilia and Ulcerative Colitis: A Case Report
Yu. M. Demenko, 
V. V. Voytsekhovsky,
L. A. Trusova,
O. A. Abuldinova,
E. I. Smorodina,
Yu. V. Suslova
V. V. Voytsekhovsky,
L. A. Trusova,
O. A. Abuldinova,
E. I. Smorodina,
Yu. V. Suslova https://doi.org/10.22448/AMJ.2026.1.43-50
EDN: TPLYDA
Abstract
The article presents a clinical observation of comorbid pathology: hematogenic thrombophilia, combined form (F5 Leiden mutation – heterozygous, MTHFR – homozygous, hyperhomocysteinemia) and ulcerative colitis. Both of these diseases have increased thrombogenicity (hereditary and acquired thrombophilia); in this case, thrombosis of the lower extremity veins, post-thrombotic syndrome, and recurrent pulmonary embolism were detected. The presence of ulcerative colitis and intestinal bleeding complicated the therapy of acute thrombosis and secondary prevention of thrombus formation. After achieving remission of ulcerative colitis, it became possible to carry out full-scale secondary prevention of thrombus formation. Subsequently, no recurrences of thrombosis were registered in this patient.
Conclusion. The possibilities of diagnosis and therapy of comorbid pathology accompanied by thrombotic complications and intestinal bleeding are demonstrated, which may be useful for practicing physicians.
Keywords
hematogenic thrombophilia,
ulcerative colitis,
comorbid pathology,
thrombotic complications,
intestinal bleeding
Supporting agencies: The study was not sponsored.
About the Authors
Yu. M. Demenko
Amur State Medical Academy
Russian Federation
Russian Federation
Yulia M. Demenko
Blagoveshchensk
V. V. Voytsekhovsky
Amur State Medical Academy
Russian Federation
Russian Federation
Valery V. Voytsekhovsky
Blagoveshchensk
L. A. Trusova
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Liliya A. Trusova
Blagoveshchensk
O. A. Abuldinova
Amur State Medical Academy
Russian Federation
Russian Federation
Olga A. Abuldinova
Blagoveshchensk
E. I. Smorodina
Amur State Medical Academy
Russian Federation
Russian Federation
Elena I. Smorodina
Blagoveshchensk
Yu. V. Suslova
Amur State Medical Academy
Russian Federation
Russian Federation
Yulia V. Suslova
Blagoveshchensk
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Review
For citations:
Demenko Yu.M., Voytsekhovsky V.V., Trusova L.A., Abuldinova O.A., Smorodina E.I., Suslova Yu.V. Combination of Hereditary Hematogenic Thrombophilia and Ulcerative Colitis: A Case Report. Amur Medical Journal. 2026;14(1):43-50. (In Russ.) https://doi.org/10.22448/AMJ.2026.1.43-50. EDN: TPLYDA
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