Pathomorphological Verification of Diffuse Pulmonary Ossification in a Patient with Acute Extensive Anterior Transmural Myocardial Infarction

Diffuse ossification of the lungs is a rare pathological process characterized by the formation of bone tissue in the lung parenchyma. In the morphological aspect, this condition differs from calcification, since it is characterized not by the deposition of calcium salts, but by the formation of mature bone tissue with a lamellar structure, osteocytes in lacunae and, in a number of observations, elements of bone marrow.

The article presents a clinicomorphological observation of a 68-year-old man who died of acute extensive anterior transmural myocardial infarction complicated by cardiogenic shock. Pathological examination revealed pronounced macroscopic changes in the lungs in the form of tissue with stony density and whitish cords. Histologically, multiple islands of immature bone tissue were detected in the interstitium and around vessels, along with thickening of the interalveolar septa, intra-alveolar edema, hemosiderosis, and microcirculatory disorders. Based on the combination of morphological signs, diffuse pulmonary ossification was diagnosed as a concomitant disease, unrecognized during life. This observation is of interest due to the rarity of this pathology and its postmortem verification in a patient whose clinical picture was dominated by acute cardiovascular disease.

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