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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">amedj</journal-id><journal-title-group><journal-title xml:lang="ru">Амурский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Amur Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-5068</issn><publisher><publisher-name>Амурская государственная медицинская академия</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22448/AMJ.2025.1.64-72</article-id><article-id custom-type="elpub" pub-id-type="custom">amedj-28</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Постковидный синдром: накопленные знания и сохраняющиеся вопросы</article-title><trans-title-group xml:lang="en"><trans-title>Post-COVID syndrome: accumulated knowledge and unresolved questions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2653-8661</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бакина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бакина Анастасия Алексеевна – к.м.н., доцент кафедры факультетской и поликлинической терапии</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Anastasia A. Bakina</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">anastasia_darchi@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8794-9929</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павленко</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlenko</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павленко Валентина Ивановна – д.м.н., доцент, заведующий кафедрой факультетской и поликлинической терапии</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Valentina I. Pavlenko</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">agmapedfac@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6059-1813</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулик</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulik</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кулик Екатерина Геннадьевна – к.м.н., доцент кафедры факультетской и поликлинической терапии</p><p>Благовещенск</p></bio><bio xml:lang="en"><p>Ekaterina G. Kulik</p><p>Blagoveshchensk</p></bio><email xlink:type="simple">rybas_katya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Амурская государственная медицинская академия» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Amur State Medical Academy Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2025</year></pub-date><volume>13</volume><issue>1</issue><fpage>64</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бакина А.А., Павленко В.И., Кулик Е.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Бакина А.А., Павленко В.И., Кулик Е.Г.</copyright-holder><copyright-holder xml:lang="en">Bakina A.A., Pavlenko V.I., Kulik E.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.amedj.ru/jour/article/view/28">https://www.amedj.ru/jour/article/view/28</self-uri><abstract><sec><title>В 2019 г</title><p>В 2019 г. мир охватила новая коронавирусная инфекция (COVID-19), признанная Всемирной организацией здравоохранения пандемией. На ранних этапах изучения COVID-19 было отмечено, что даже после исчезновения острых симптомов заболевания в течение длительного времени пациентов продолжает беспокоить целый спектр неспецифических жалоб, снижающих качество жизни. Данное состояние получило название «постковидного синдрома» (ПКС).</p><p>Цель обзора – проанализировать и обобщить данные российских и зарубежных исследований, посвященных изучению патогенетических особенностей развития и клинических проявлений ПКС.</p><p>Основные положения обзора. Первые упоминания о длительно сохраняющихся неспецифических симптомах, беспокоящих пациентов после выздоровления вследствие перенесенной COVID-19, появились в начале 2020 г. Позже специалисты обратили внимание, что все чаще поводом для визита к лечащему врачу становятся неспецифические жалобы (немотивированная общая слабость и вялость, болевой синдром, одышка). Чаще всего симптомы беспокоили лиц пожилого возраста, однако дальнейшие исследования показали, что дети и подростки подвержены развитию ПКС не в меньшей степени. Всесторонний подход изучению патогенеза ПКС продемонстрировал целый спектр механизмов его формирования.</p></sec><sec><title>Заключение</title><p>Заключение. Изучение феномена ПКС требует учитывать сложность его патогенетических механизмов и мультисистемность проявлений. Исследователям еще предстоит решить множество вопросов для формирования единой целостной картины заболевания и поиска эффективных способов помощи пациентам с ПКС.</p></sec></abstract><trans-abstract xml:lang="en"><p>In 2019, a novel coronavirus infection (COVID-19) emerged globally and was declared a pandemic by the World Health Organization. Early studies of COVID-19 revealed that even after resolution of acute symptoms, patients continued to experience a wide range of nonspecific complaints that significantly impaired quality of life for prolonged periods. This condition became known as “postCOVID syndrome” (PCS).</p><p>Objective of the review is to analyze and summarize data from Russian and international studies focusing on the pathogenetic mechanisms and clinical manifestations of PCS. ,</p><p>Main findings. Initial reports of persistent nonspecific symptoms following recovery from COVID-19 appeared in early 2020. Subsequently, healthcare providers increasingly noted that nonspecific complaints – such as unexplained general weakness, fatigue, pain syndromes, and dyspnea – were becoming common reasons for patient visits. Initially thought to primarily affect older adults, further research indicated that children and adolescents are similarly susceptible to developing PCS. A comprehensive investigation into the pathogenesis of PCS has revealed multiple underlying mechanisms contributing to its development. Conclusion. Understanding the phenomenon of PCS requires acknowledging the complexity of its pathogenetic mechanisms and the multisystem nature of its manifestations. Researchers still face numerous unresolved questions in establishing a unified, comprehensive understanding of the disease and identifying effective therapeutic strategies for patients with PCS.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пандемия</kwd><kwd>коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>постковидный синдром</kwd><kwd>патогенетические механизмы</kwd><kwd>неспецифические жалобы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pandemic</kwd><kwd>coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>post-COVID syndrome</kwd><kwd>pathogenetic mechanisms</kwd><kwd>nonspecific symptoms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chan J.F., Yuan S., Kok K.H., et al. 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